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Combo-pilling will be the newest fad or even better the newest ahead under scrutiny and so it is just more publicly known although in the past, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is now popular could be the fact that at the time of right now there aren't long term prescription weight loss supplements that have been approved by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be authorized by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug could also raise hypertension and heart rate, and shouldn't be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must stop used in patients with uncontrolled high blood pressure level, in addition to by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients using a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert medical professionals and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking. Approving a drug with this particular many potentially lethal unwanted side effects is inconsistent with the mission statement in the FDA. The power of the drug manufacturing lobby is blatantly evident within the approval of numerous drugs requiring 'post-marketing' studies that are clearly significant to overall drug safety inside US.